Carl A. Sirio

Dr. Carl A. Sirio, a board-certified internist and critical care physician, is a Senior Advisor at Discern Health. As a seasoned health care executive and a leading voice in health systems improvement, Carl has devoted his career to working toward health care quality, safety, access, and equity. At Discern, Carl uses his experience as a clinician, academician, and health system administrator to help clients test and implement initiatives that measure and improve quality and translate measurement into on-the-ground benefits to patient care.

Prior to affiliating with Discern, Carl spent 17 years at the University of Pittsburgh Medical Center. From there he became Chief Operating and Clinical Officer and Senior Associate Dean for clinical affairs at the University of Toledo (UT), where his innovative approaches to health systems improvement earned the university numerous awards for excellence. Carl also served as the UT Vice President for Medical Affairs/Chief Medical Officer and Chief Medical Information Officer.

In addition, Carl co-founded the Pittsburgh Regional Healthcare Initiative, a nationally recognized collaboration that improved care throughout the region, and was the recipient of several large grants from the Agency for Healthcare Research and Quality to create meaningful improvement in the care of patients. He also worked with the National Quality Forum, the Centers for Disease Control and Prevention, the National Institute of Medicine, and the US Pharmacopeia, among others, to improve patient care quality and safety.

Carl is the founder of Sirio2 Healthcare Innovations, LLC, which builds on his decades of health care leadership experience with a vision for strategically and practically improving clinical care across all settings. He also has contributed to numerous health care policymaking boards, including as a Trustee for the American Medical Association and The Joint Commission.

Carl completed his undergraduate and medical school training at Columbia University and Rutgers Medical School, and he completed postgraduate medical training at the Milton S. Hershey Medical Center at Pennsylvania State University, the National Institutes of Health, and George Washington University.

Areas of Expertise

  • Health system leadership, operations, and management
  • Clinical systems design and utilization
  • Outcomes assessment, clinical quality and safety, and patient experience and engagement


  • MD – University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School (Rutgers)
  • BA, History – Columbia University

Honors and Awards

  • Fellow, American College of Physicians
  • Fellow, American College of Critical Care Medicine
  • Fellow, American College of Chest Physicians

New Report: Recommendations for Patient and Family Engagement in Measure Development

Harnessing the stories, ideas, and innovations of patient and caregiver partners is the key to making measurement meaningful. With support from the Patient-Centered Outcomes Research Institute (PCORI)...
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